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Papers
Optimized Spatial Configuration of Heterogeneous Biocatalysts Maximizes Cell-Free Biosynthesis of ω-Hydroxy and ω-Amino Acids
Santiago-Arcos, J., Velasco-Lozano, S., Diamanti, E., Benítez-Mateos, A. I., Grajales-Hernández, D., Paradisi, F., López-Gallego, F.
ACS Sustain. Chem. Eng. 2024, 12: 9474-9489.
Towards Greener and More Cost-efficient Biosynthesis of Pharmaceuticals and Fragrance Molecules
Benítez-Mateos, A. I.*
CHIMIA. 2024, 78: 222-225.
Special Issue "Laureates: Junior Prizes Fall Meeting 2023"
Local environment in biomolecular condensates modulates enzymatic activity across length scales
Gil-Garcia, M., Benítez-Mateos, A. I., Papp, M., Stoffel, F., Morelli, C., Normak, K., Makasewicz, K., Faltova, L., Paradisi, F., Arosio, P.
Nature Communications. 2024, 15: 3322.
Biocatalytic Synthesis of L-Pipecolic Acid by a Lysine Cyclodeaminase: Batch and Flow Reactors
Stalder, K., Benítez-Mateos, A. I.*, Paradisi, F.*
ChemCatChem. 2024, e202301671.
Special Issue "Catalysis Talents" of ChemCatChem
Perspectives on Flow Biocatalysis: The Engine Propelling Enzymatic Reactions
Benítez-Mateos, A. I.*, Paradisi, F.*
Journal of Flow Chemistry. 2023, 14: 211-218.
Special Issue "Emerging Investigators" of Journal of Flow Chemistry
Halomonas elongata: a microbial source of highly stable enzymes for applied biotechnology
Benítez-Mateos, A. I.*, Paradisi, F.*
Applied Microbiology and Biotechnology. 2023, 107: 3183-3190.
Spheroplast preparation boosts the catalytic potential of a squalene-hopene cyclase
Benítez-Mateos, A. I., Schneider, A., Hegarty, E., Hauer, B., Paradisi, F.
Nature Communications. 2022, 13: 6269.
Novel triple mutant of an extremophilic glycosyl hydrolase enables the rapid synthesis of thioglycosides
Pillet, L., Lim, D., Almulhim, N., Benítez-Mateos, A. I., Paradisi, F.
Chemical Communications. 2022, 58: 12118-12121.
21.
Fusion of formate dehydrogenase and alanine dehydrogenase as an amino donor regenerating system coupled to transaminases
Marchini, V., Benítez-Mateos, A. I., Hutter, S. L., Paradisi, F.
ChemBioChem. 2022, 22: e202200428.
20.
A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow
Benítez-Mateos, A. I., Klein, C., Roura Padrosa, D., Paradisi, F.
Catalysis Science and Technology. 2022, 12: 6231-6238
Multi-step enzyme cascades as a route towards green and sustainable pharmaceutical syntheses
Benítez-Mateos, A. I., Roura Padrosa, D., Paradisi, F.
Nature Chemistry. 2022, 14: 489-499.
18.
17.
Sustainable flow-synthesis of (bulky)nucleoside drugs by a novel and highly stable nucleoside phosphorylase immobilized on reusable supports
Benítez-Mateos, A. I., Paradisi, F.
ChemSusChem. 2022, 15: e2021020.
16.
Chimeric fusion of glutamate dehydrogenase and formate dehydrogenase yields a bifunctional efficient biocatalyst for the continuous removal of ammonia
Marchini, V., Benítez-Mateos, A. I., Roura Padrosa, D., Paradisi, F.
Frontiers in Catalysis. 2021, 1: 790461.
Agarose vs methacrylate as material supports for enzyme immobilisation and continuous processing
Benítez-Mateos, A. I., Contente, M. L.
Catalysts. 2021, 11: 814.
"Catalysts 2021 Highly-cited paper award" of the Biocatalysis Section
14.
Dual revalorization of lignin through its use as a versatile and renewable matrix for enzyme immobilisation and (flow)bioprocess engineering
Benítez-Mateos, A. I., Bertella, S., De Bueren, J. B., Luterbacher, J., Paradisi, F.
ChemSusChem. 2021, 14: 3198-3207.
Selected as “ChemSusChem Readers choice August 2021”
13.
Flow biocatalysis 101: design, development and applications
Benítez-Mateos, A. I., Contente, M. L., Roura Padrosa, D., Paradisi, F.
Reaction Chemistry and Engineering. 2021, 6: 599-611
Ranked in the top 5% of highly cited works from RSC Journals
Solid phase assembly of multi-enzyme systems into artificial cellulosomes
Zeballos, N., Diamanti, E., Benítez-Mateos, A. I., Schmidt-Dannert, C., López-Gallego, F.
Bioconjugate Chemistry. 2021, 9: 2971-2978.
11.
Cell-free biocatalytic syntheses of L-pipecolic acid: a dual strategy approach and process intensification in flow
Roura Padrosa, D.,# Benítez-Mateos, A. I., # Calvey, L., Paradisi, F.
Green Chemistry. 2020, 22: 5310-5316.
Selected as a 2020 “HOT Green Chemistry" article
Featured by OPRD in the "2020 highlights"
10.
Micro-compartmentalized cell-free protein synthesis in hydrogel μ-channels
Benítez-Mateos, A. I.,* Zeballos, N., Comino, N., Moreno-de-Redrojo, L., Randelovic, T., López-Gallego, F.*
ACS Synthetic Biology. 2020, 9: 2971-2978.
Design of the enzyme-carrier interface to overcome the O2 and NADH mass transfer limitations of an immobilized flavin-oxidase
Benítez-Mateos, A. I., Huber, C., Nidetzky, B., Bolivar, J. M., López-Gallego, F.
ACS Applied Materials & Interfaces. 2020, 12: 56027-56038.
8.
Deciphering the effect of microbead size distribution
on the kinetics of heterogeneous biocatalysts through
single-particle analysis based on fluorescence microscopy
Muñoz-Morales, E., Velasco-Lozano, S., Benítez-Mateos, A. I., Marín, M. J., Ramos-Cabrer, P., López-Gallego, F.
Catalysts. 2019, 9: 896.
7.
Selective immobilisation of fluorescent proteins for the fabrication of photoactive materials
Benítez-Mateos, A. I., Mehravar, E., Velasco-Lozano, S., Tomovska, R., Salassa, L., López-Gallego, F.
Molecules. 2019, 24: 2775.
Self-sufficient flow-biocatalysis by coimmobilisation of pyridoxal 5′-phosphate and ω-transaminases onto porous carriers
Benítez-Mateos, A. I., Contente, M. L., Velasco-Lozano, S., Paradisi, F., López-Gallego, F.
ACS Sustainable Chemistry & Engineering. 2018, 6: 13151-13159.
5.
Expanding one-pot cell-free protein synthesis and immobilisation for on-demand manufacturing of biomaterials
Benítez-Mateos, A. I., Llarena, I., Sánchez-Iglesias, A., López-Gallego, F.
ACS Synthetic Biology. 2018, 7: 875-884.
4.
Chemoenzymatic approaches to the synthesis of the calcimimetic agent cinacalcet employing transaminases and ketoreductases
Marx, L., Ríos-Lombardía, N., Farnberger, J., Kroutil, W., Benítez-Mateos, A. I., López-Gallego, F., Morís, F., González-Sabín, J., Berglund, P. Advanced Synthesis & Catalysis. 2018, 360: 2157-2165.
Single-particle studies to advance the characterization of heterogeneous biocatalysts
Benítez-Mateos, A. I., Nidetzky, B., Bolivar, J. M., López-Gallego, F.
ChemCatChem. 2017, 10: 654- 665.
Selected as “Very important paper” by ChemCatChem
2.
Asymmetric reduction of prochiral ketones by using self-sufficient heterogeneous biocatalysts based on NADPH-dependent ketoreductases
Benítez-Mateos, A. I., San Sebastián, E., Ríos-Lombardía, N., Morís, F., González-Sabín, J., López Gallego, F.
Chemistry – A European Journal. 2017, 23: 16843-16852.
1.
Co-immobilized phosphorylated cofactors and enzymes as self-sufficient heterogeneous biocatalysts for chemical processes
Velasco-Lozano, S., Benítez-Mateos, A. I., López-Gallego, F.
Angew. Chem. Int. Ed. 2017, 56: 771-775.
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